Our goal is to construct synthetic molecular systems to study complex biological phenomena, and to engineer genetic circuits for manipulation of cells, especially mammalian cells in a non-destructive way. Specifically, we are interested to link molecular information processing with cellular decision making and apply this technology platform to addressing key challenges in biomedical and biotechnology applications. Our major research areas:
- Construction of parts and motifs for synthetic biology research
- Automation for gene synthesis and genetic circuit assembly
- Genetic circuit engineering for gene therapy and cell-based therapy
- Integrative biomolecular sensing and processing for cellular automation
- Congratulations to Dacheng & Shuguang on the split dCas9 paper!
- Congratulations to Bing and Ye on the microRNA-ceRNA paper!
- A transcription repressor toolkit made of TALE DNA binding scaffold for genetic circuit engineering
- Transcripts for combined synthetic microRNA and gene delivery