清华合成与系统生物学中心
Tsinghua Center for Synthetic and Systems Biology
李梢
李 梢 (Shao Li)
教授
清华大学自动化系、医学院
清华信息科技国家实验室(筹)生物信息学部副主任
国家杰出青年基金获得者




联系方式

电子邮件:
shaoli@tsinghua.edu.cn

教育背景及工作履历
清华大学    教授(2009.12至今)
清华大学   博士生导师(2008.9至今)
清华信息科技国家实验室(筹)生物信息学研究部  副主任 (2006.2至今)
清华大学自动化系  副研究员 (2004.12-2009.11)
清华大学自动化系 讲师 (2003.8-2004.12)
清华大学自动化系  博士后 (2001.9-2003.8)
北京中医药大学 医学博士(1998.9-2001.7)
皖南医学院 医学硕士(1995.9-1998.7)
北京中医药大学 医学学士(1990.9-1995.7)

科研方向
炎症与肿瘤的分子网络;
中药网络药理学


主要论文 (*: Corresponding Author)
Li S*, Zhang B. Traditional Chinese medicine network pharmacology: theory, methodology and application (Invited review).
Chinese Journal of Natural Medicines 2013 (In Press)
Zhang B, Wang X, Li S*. An integrative platform of TCM network pharmacology and its application on an herbal formula, Qing-Luo-Yin.
Evidence-based Complementary and Alternative Medicine 2013:456747
Zhang B, Liu L, Zhao S, Wang X, Liu L, Li S*. Vitexicarpin acts as a novel angiogenesis inhibitor and its target network.
Evidence-based Complementary and Alternative Medicine 2013:278405
Jiang B, Liang X, Chen Y, Ma T, Liu L, Li J, Jiang R, Chen T, Zhang X*, Li S*. Integrating next-generation sequencing and traditional tongue diagnosis to determine tongue coating microbiome. Scientific Reports 2012;2:936, pages:1-12

Zhao S,
Li S*. A co-module approach for elucidating drug-disease associations and revealing their molecular basis. Bioinformatics (published online January 28, 2012, doi:10.1093/bioinformatics/bts057)
Chen Y, Gu J, Li D,
Li S*. Time-course network analysis reveals TNF-alpha can promote G1/S transition of cell cycle in vascular endothelial cells. Bioinformatics 2012;28(1):1-4
Li S*, Zhang B, Zhang NB. Network target for screening synergistic drug combinations with application to traditional Chinese medicine. BMC Systems Biology 2011;5(S1):S10
Yao X, Hao H, Li Y,
Li S*. Modularity-based credible prediction of disease genes and detection of disease subtypes on the phenotype-gene heterogeneous network. BMC Systems Biology 2011;5:79
Lu L, Li Y,
Li S*. Computational identification of potential microRNA network biomarkers for the progression stages of gastric cancer. International Journal of Data Mining and Bioinformatics 2011;5:519-531
Li S*, Zhang B, Jiang D, Wei YY, Zhang NB. Herb network construction and co-module analysis for uncovering the combination rule of traditional Chinese herbal formulae. BMC Bioinformatics 2010;11(S11):S6
Zhao S,
Li S*. Network-based relating pharmacological and genomic spaces for drug target identification. PLoS ONE 2010;5(7):e11764
Yan H, Zhang B,
Li S*, Zhao Q*. A formal model for analyzing drug combination effects and its application in TNF-alpha-induced NFkappaB pathway. BMC Systems Biology 2010;4:50
Ma T, Tan C, Zhang H, Wang M, Ding W,
Li S*. Bridging the gap between traditional Chinese medicine and systems biology: the connection of Cold Syndrome and NEI network. Molecular BioSystems 2010;6:613-619
Gu J, Chen Y,
Li S*, Li Y*. Identification of responsive gene modules by network-based gene clustering and extending: application to inflammation and angiogenesis. BMC Systems Biology 2010;4:47
Huang Y,
Li S*. Detection of characteristic sub pathway network for angiogenesis based on the comprehensive pathway network. BMC Bioinformatics 2010;11(S1):S32
Li LS, Zhang NB,
Li S*. Ranking effects of candidate drugs on biological process by integrating network analysis and Gene Ontology. Chinese Science Bulletin 2010;55:2974-2980
Yao BP,
Li S*. ANMM4CBR: a case-based reasoning method for gene expression data classification. Algorithms for Molecular Biology 2010;5:14
Li S, Lu A*, Wang Y. Symptomatic comparison in efficacy on patients with benign prostatic hyperplasia treated with two therapeutic approaches. Complementary Therapies in Medicine 2010;18:21-27
Li S. Network systems underlying traditional Chinese medicine syndrome and herb formula. Current Bioinformatics 2009;4(3):188-196
Wu X, Jiang R, Zhang MQ,
Li S*. Network-based global inference of human disease genes. Molecular Systems Biology 2008;4:189
Zhang J, Ma T, Li YD,
Li S*. dbNEI2.0: building multilayer network for drug-NEI-disease. Bioinformatics 2008;24:2409-2411
Kang G,
Li S*, Zhang JF. Entropy-based model for interpreting life systems in traditional Chinese medicine. Evidence-based Complementary and Alternative Medicine 2008;5(3):273-279
Wu M, Ma C, Wu Y,
Li S*. Simultaneous LC analysis of five bioactive alkaloids in an anti-angiogenesis herbal formula, Qing-Luo-Yin. Chromatographia 2008;68:579-585
Li S*, Zhang Z, Wu L, Zhang X, Li Y, Wang Y. Understanding ZHENG in traditional Chinese medicine in the context of neuro-endocrine-immune network. IET Systems Biology 2007;1(1):51-60
Li S*, Fang YH. Modelling circadian rhythms of protein KaiA, KaiB and KaiC interactions in cyanobacteria. Biological Rhythm Research 2007;38(1):43-53
Li S*, Wu LJ, Zhang ZQ. Constructing biological networks through combined literature mining and microarray analysis: a LMMA approach. Bioinformatics 2006;22:2143-2150
Zhuang YL,
Li S*, Li YD. dbNEI: a specific database for neuro-endocrine-immune interactions. Neuroendocrinology Letters 2006,27(1/2): 53-59
Li S*, Wang R, Zhang Y, Zhang X, Layon AJ, Li Y, Chen M. Symptom combinations associated with outcome and therapeutic effects in a cohort of cases with SARS. American Journal of Chinese Medicine 2006, 34(6):937-947
Li S*, Lu A, Li B, Wang Y. Circadian rhythms on hypothalamic-pituitary-adrenal axis hormones and cytokines of collagen induced arthritis in rats. Journal of Autoimmunity 2004;22(4):277-285
Li S*, Lu AP, Wang YY, Li YD. Suppressive effects of a Chinese herbal medicine Qing-Luo-Yin extract on the angiogenesis of collagen induced arthritis in rats. American Journal of Chinese Medicine 2003,31(5): 713-720


发明专利
1.Li S, Zhang NB, Zhang B. Method of Network-Based Identification of Multicomponent Synergy and Compositions for Use as Effective Component of Anti-Angiogenesis Medicines. 美国发明专利. 专利号:US Patent: 12/436,844
2.李梢,赵世文. 基于蛋白质网络的药物靶标确定和/或药物功能确定方法.申请中国发明专利、PCT专利.申请号:201010218468.X
3.李梢,张宁波,张博. 基于基因网络的药物组合协同作用确定方法.授权中国发明专利. ZL200810239284.4
4.李梢,吴敏.一种具有抗血管新生协同作用的中药有效成分组合.授权中国发明专利. 专利号:ZL200610114226.X


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