Version 1.0 database for neuro-endocrine-immune (dbNEI), which can be accessed at http://bioinfo.au.tsinghua.edu.cn/dbNEIweb1.0/, is a web-based knowledge resource specific for the NEI systems. It provides a knowledge environment for understanding the main regulatory systems of NEI in a molecular level. dbNEI collects 1,058 NEI related signal molecules, their 940 interactions and 72 affiliated tissues from the Cell Signaling Networks database and manually selects 982 NEI papers from PubMed. NEI related information, such as signal transductions, regulations and control subunits, are integrated. Especially, dbNEI represents as graphic visualization, by which control subunits can be automatically obtained according to the inquiring issues.

Version 2.0: We updated the database in four aspects.
1. Recruiting new NEI genes and compounds.
2. Adding KEGG,HPRD,Transcription factor and microRNA target relations.
3. Collecting drug-gene and disease-gene relation.
4. Building multi-layer network for drug-NEI-disease.
The database stucture is showed in the following figure.

Publication:
dbNEI 1.0: Zhuang, Y., Li, S*. and Li, Y. dbNEI: a specific database for neuro-endocrine-immune interactions, Neuro endocrinology letters, 2006, 27:53-59.
dbNEI 2.0: Zhang, J., Ma, T., Li, Y. and Li, S.*. dbNEI2.0: building multilayer network for drug-NEI-disease. Bioinformatics 2008;24:2409-2411