ClustEx: identification of responsive gene modules by network-based gene clustering and extending [2012/05/03 Updated, v0.32]


Citation: Jin Gu, Yang Chen, Shao Li, Yanda Li. Identification of responsive gene modules by network-based gene clustering and extending: application to inflammation and angiogenesis. BMC Systems Biology 2010, 4:47.

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clustex-0.31_eppstein (extended with non-simple k-shortest paths)

clustex-0.31_KSP (extended with simple k-shortest paths)

clustex-0.1 (original package)

clustex-0.32_eppstein (extended with non-simple k-shortest paths) [Latest Version]


1. The biggest responsive gene modules

    Figure 2. TNF   responsive module (284 genes)            [View & Download]

    Figure 4. VEGF responsive module (262 genes)            [View & Download]


2. Reference responsive gene sets (only include the genes both in Affy U133Plus2/U133A platform and HPRD release 7)

    TNFLitRef (376 genes, retrieved 998 abstracts from PubMed, processed by Agilent Literature Cytoscape plug-in)

 

    TNFNetPathRef (184 genes, NetPath database TNF/NF-kB signaling pathway)

 

    TNFPathDBRef (63 genes, BioCarta/PID/Reactome related pathways)

 

    VEGFLitRef (342 genes, retrieved 871 abstracts from PubMed, processed by Agilent Literature Cytoscape plug-in)

 

    VEGFPathDBRef (109 genes, BioCarta/PID/KEGG related pathways)


3. dChip processed signal files (log-transformed)

    TNF (GSE9055, TNF 10ng/ml, HUVEC, 0~8h, 25 time points, Affy Human U133Plus2.0 & HPRD7)        [Download]

 

    VEGF (GSE10778, VEGF 100ng/ml, HUVEC, 0~6h, 5 time points, Affy Human U133A & HPRD7)           [Download]


4. Fold changes (log-transformed: 1 = 2 fold change) & expression correlations

    TNF         Fold_changes         Expression_correlations

 

    VEGF       Fold_changes         Expression_correlations


Any problem please contact Jin Gu (wellgoo at gmail dot com)

Personal site (http://bioinfo.au.tsinghua.edu.cn/member/~gujin/)