Michael Q. Zhang
张奇伟 教授
（Michael Q. Zhang）
信息学院与医学院双聘教授，生命学院兼职教授
博士生导师
清华信息国家实验室合成与系统生物实验室主任
首批千人计划教授， 长江学者讲座教授
Email:

mzhang(_AT_)cshl(_DOT_)edu

michaelqiweizhang(_AT_)gmail(_DOT_)com


主要科研领域与方向  Top

      计算生物学与生物信息学，合成生物与系统生物学，特别是利用高通量组学技术和高性能计算机模拟，研究细胞发育、分化、凋亡的基因调控和代谢网络，以及它们在癌症等疾病、生物能源、和环境中的应用。

研究及工作经历  Top

  • 1977-1981 中科大近代力学系， 学士
  • 1981-1987 Rutgers U， 统计物理博士
  • 1987-1991 美国NYU Courant Inst.，应用数学博士后
  • 1991-1996 美国冷泉港实验室基因组研究Fellow
  • 1996-1998 美国冷泉港实验室，Assistant Staff
  • 1999-2001 美国冷泉港实验室，Associate Professor
  • 2002-2010 美国冷泉港实验室， Full Professor
  • 2009-至今 清华大学信息学院与医学院双聘教授，生命学院兼职教授， 博导，清华信息国家实验室合成与系统生物实验室主任
  • 2010-至今 美国UT Dallas，Cecil H. and Ida Green Distinguished Chair Professor， Director of Center for Systems Biology

发表论文及著作：  Top

2011

  • Chen L, Zhang H, Li L, Yan Z, Wu DM, Liu Y, Liu K, Liu M, Hu L, Tu Q, Chang Y, Tan Y, Yang C, Song D, Fu J, Yang X, Feng Q, Chen H, Wu M, Yang H, Zhang MQ, Zhang Y, Wang J, Wang H (2011) Integrative whole genome analyses revealing clonal HBV integrations and abnormal enrichment of variable number tandem repeats in human hepatocellular carcinoma. J. Clinical Invest. Submitted.
  • Ma X, Kulkarni A, Zhang Z, Xuan Z, Zhang MQ (2011) POSMO: A highly efficient and effective motif discovery method for ChIP-seq/ChIP-chip data using positional information. Submitted.
  • Wu J, Akerman M, Sun S, McCombie WR, Krainer AR, Zhang MQ (2011) SpliceTrap: a method to quantify alternative splicing under single cellular conditions. Bioinformatics, in press.
  • Dai Q, Lihua Li L, Liu X, Yao Y, Zhao F, Zhang M(2011) Integrating overlapping structures and background information of words significantly improves biological sequence comparison. PLoS ONE, submitted.
  • Shen M, Eyras E,Wu J, Khanna A, Josiah S, Rederstorff M, Zhang MQ, Stamm S (2011) Direct cloning of double-stranded RNAs from RNAse protection analysis reveals processing patterns of C/D box snoRNAs and provides evidence for widespread antisense transcript expression. NAR, In press.
  • Watts JA, Zhang C, Klein-SzantoAJ，Kormish JD, Zhang MQ, Zaret K, (2011) Study of FoxA Pioneer Factor at Silent Genes Reveals Rfx-Repressed Enhancer at Cdx2 and a Potential Indicator of Esophageal Adenocarcinoma Development. PLoS Genet. In press.
  • Rajan P, Dalgliesh C, Carling P, Buist T, Zhang C, Grellscheid SN, Armstrong K, Stockley J, Simillion C, Gaughan L, Kalna G, Zhang MQ, Robson CN, Leung HY, Elliott DJ. (2011) Identification of novel androgen-related pathways and mRNAs isoforms through genome-wide exon-specific profiling of LNCaP transcriptome. Endocrine-Related Cancer, Submitted.
  • Zhang Z, Zhang MQ (2011) Histone modification profiles are predictive for both protein-coding and microRNA gene’s tissue.cell-type specific expression. BMC Bioinformatics. In press.
  • Yang S, Yalamanchili HK, Li X, Yao K-M, Sham PC, Zhang MQ, Wang J. (2011) Correlated evolution of transcription factors and their binding sites. NAR, In press.
  • Qin J, Li M, Wang P, Zhang MQ, Wang J (2011) ChIP-Array: combinatory analysis of ChIP-seq/chip and microarray gene expression data to discover direct/indirect targets of a transcription factor. NAR, in press.
  • Kato M, Yoon S, Hosono N, Leotta A, Sebat J, Tsunoda T, Zhang MQ (2011) Inferring Haplotype of Copy Number variations from High-throughput data with Uncertainty. Genetics, In press.
  • Kato M, Yoon S, Hosono N, Leotta A, Sebat J, Tsunoda T, Zhang MQ (2011) Inferring Haplotype of Copy Number variations from High-throughput data with Uncertainty. Genetics, In press.
  • Valérie M. Renault, Pramod U. Thekkat, Kimmi L. Hoang, Jamie L. White, Colleen A. Brady, Daniela Kenzelmann, Ophelia S. Venturelli, Thomas M. Johnson, Zhenyu Xuan, Evan E. Santo, Michael Q. Zhang, Hannes Vogel, Laura D. Attardi, Anne Brunet (2011) The pro-longevity gene FoxO3 is a direct target of the p53 tumor suppressor. Oncogene, In press.
  • Zhang MQ, (2011) Computational Promoter Prediction in a Vertebrate genome. Chap. In Handbook of Statistical Bioinformatics. Springer Handbooks of Computational Statistics. Lu H, Scholkopf B and Zhao H (Eds). In press. ISBN: 978-3-642-16344-9. [Link]

>> 更多

Updated on Aug. 29, 2011