Michael Q. Zhang
张奇伟 教授
（Michael Q. Zhang）

信息学院与医学院双聘教授
生命学院兼职教授
博士生导师
清华信息国家实验室合成与系统生物实验室主任
首批千人计划教授
长江学者讲座教授

  Email:

michaelzhang@tsinghua.edu.cn

michael.zhang@utdallas.edu


主要科研领域与方向  Top

计算生物学与生物信息学，合成生物与系统生物学，特别是利用高通量组学技术和高性能计算机模拟，研究细胞发育、分化、凋亡的基因调控和代谢网络，以及它们在癌症等疾病、生物能源、和环境中的应用。

研究及工作经历  Top

  • 1977-1981 中科大近代力学系， 学士
  • 1981-1987 Rutgers U， 统计物理博士
  • 1987-1991 美国NYU Courant Inst.，应用数学博士后
  • 1991-1996 美国冷泉港实验室基因组研究Fellow
  • 1996-1998 美国冷泉港实验室，Assistant Staff
  • 1999-2001 美国冷泉港实验室，Associate Professor
  • 2002-2010 美国冷泉港实验室， Full Professor
  • 2009-至今 清华大学信息学院与医学院双聘教授，生命学院兼职教授， 博导，清华信息国家实验室合成与系统生物实验室主任
  • 2010-至今 美国UT Dallas，Cecil H. and Ida Green Distinguished Chair Professor， Director of Center for Systems Biology

发表论文及著作：  Top

2012

  • Xie W, Schultz M, Lister R, Hou Z, Rajagopal N, Ray P, Whitaker JW, Tiam S, Hawkins DR, Leung D, Yang H, Wang T, Swanson SA, Zhang J, Zhu Y, Lee AY, Kim A, Nery J, Urich MA, Kuan S, Yen C, Klugman S, Yu P, Suknuntha K, Propson NE, Chen H, Edsall LE, Wagner U, Li Y, Ye Z, Kulkarni A, Xuan Z, Chung W, Chi NC, Antosiewicz-Bourget J, Slukvin I, Stewart R, Zhang MQ, Wang W, Thomson JA, Eckert JR, Ren B (2013) Epigenomic Analysis of Multi-lineage Differentiation of Human Embryonic Stem Cells. Cell, In press.
  • Wen-Yu Chung, Robert J. Schmitz, Tanya Biorac, Delia Ye, Miroslav Dudas, Gavin D. Meredith, Christopher C. Adams, Joseph R. Ecker and Michael Q. Zhang (2013) Constructing hepitypes: phasing local genotype and DNA methylation. JNSNE, In press.
  • Megha Rajaram; Jianping Zhang; Tim Wang; Cem Kuscu; Mamoru Kato; Vladimir Grubor; Robert Weil; Asluag Helland; Anne-Lise Borrenson-Dale; Kathleen Cho; Douglas A Levine; Alan N Houghton; Jedd D Wolchok; Lois Myeroff; Sanford D Markowitz; Michael Zhang; Alex Krasnitz; Robert Lucito; David Mu; Scott Powers (2013) Two Distinct Categories of Focal Deletions in Cancer Genomes. PLoS ONE, submitted.
  • Akerman M, Zhang MQ, Krainer A. (2013) ProteoMirExpress: inferring microRNA-centered regulatory networks from high throughput proteomic and mRNA expression data. MCP, Submitted.
  • Tang MH, Varadan V, Kamalakaran S, Zhang MQ, Dimitrova N, Hicks J. (2013) Major chromosomal breakpoint intervals in breast cancer co-localize with differentially methylated regions. Front Oncol. 2:197. PMID:23293768
  • Xing H, Liao W, Mo Y, Zhang MQ. （2012）A Novel Bayesian Change-point Algorithm for Genome-wide Analysis of Diverse ChIPseq Data Types. J Vis Exp, Dec 10;(70). doi:pii: 4273. We H*, Li Y*, Malek SN, Kim YC, Xu J, Chen P, Xiao F, Huang X, Zhou X, Xuan Z, Mankala S, Rowley JD, Zhang MQ, Wang SM (2012) New fusion transcripts identified in normal karyotype acute myeloid leukemia. PLoS ONE. 7:e51203.
  • Ouyang W, Will L, Luo CT, Yin N, Huse M, Kim MV, Peng M, Chan P, Ma Q, Mo Y, Meijer D, Zhao K, Rudensky AY, Atwal G, Zhang MQ*, Li MO* (2012) Novel Foxo1-dependent Transcriptional Programs Control Treg Cell Function. Nature. In press.
  • Xing H, Liao W, Mo Y, Zhang MQ (2012) A Novel Bayesian Change-point Algorithm for Genome-wide Analysis of Diverse ChIPseq Data Types. J Vis Exp, Dec 10;(70). doi:pii: 4273.
  • Xing H*, Mo Y, Liao W, Zhang MQ* (2012) Genomewide localization of protein-DNA binding and histone modification by BCP with ChIP-seq data. PLoS CB, 8(7): e1002613.
  • Sleumer MC, Wei G, Wang Y, Chang H, Xu T, Chen R, Zhang MQ (2012) Regulatory elements of Caenorhabditis elegans ribosomal protein genes. BMC Genomics. 13:433. PMID:22401550.
  • Li R, Guo W, Gu J, Zhang MQ, Wang XW (2012) Chromatin state and microRNA determine different gene expression dynamics responsive to TNF stimulation. Genomics. [Epub ahead of print] PMID:22824656..
  • Zhang Z, Ma X, Zhang MQ (2012) Bivalent-like chromatin markers are predictive for transcription start site distribution in human. PLoS ONE, 7:e38112. PMID:22768038.
  • Chicas A*, Kapoor A*, Wang X*, Evertts AG, Benjam G, Zhang MQ, Bernstein E, Lowe SW, (2012) H3K4 demethylation by Jarid1a and Jarid1b contributes to RB-mediated gene silencing during cellular senescence. PNAS, 109:8971-6. PMID:22615382.
  • Zhang J, Wu Z, Gao C, Zhang MQ (2012) High-order interactions in Rheumatoid Arthritis detected by Bayesian method using GWAS data. American Medical Journal, 3:56-66.
  • Zhang C, Zhang MQ (2012) Identification of Splicing Factor Target Genes by High-throughput Sequencing. Chap. 51 in Alternative pre-mRNA Splicing: Theory and Protocols. Eds. Stamm S, Smith C, Luhrmann R. Wiley-Blackwell, Weinheim, Germany.
  • Zhang MQ (2012), Dissecting Splicing Regulatory Network by Integrative Analysis of CLIP-Seq Data. Chap 12 in Bioinformatics for High Throughput Sequencing, eds. Rodriguez-Ezpeleta N, Hackenberg M, Aransay AM. p209. ISBN978-1-4614-0781-2, Springer.
  • Zhang J, Zhang Q, Lewis D, Zhang MQ (2012) A Bayesian Method for Disentangling Dependent Structure of Epistatic Interaction. Am. J. Biostat., 2:1-10.
  • He M, Liu Y, Wang X, Zhang MQ, Hannon GJ, Huang ZJ (2012) Cell-type based analysis of microRNA profiles in the mouse brain. Neuron. 73:35-48. PMID:22243745.
  • Ma X, Kulkarni A, Zhang Z, Xuan Z, Serfling R, Zhang MQ (2012) POSMO: A highly efficient and effective motif discovery method for ChIP-seq/ChIP-chip data using positional information. Nucl. Acid. Res. PMID:22228832.
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Updated on April. 5, 2012