Michael Q. Zhang
张奇伟 教授
(Michael Q. Zhang)

信息学院与医学院双聘教授
生命学院兼职教授
博士生导师
清华信息国家实验室合成与系统生物实验室主任
首批千人计划教授
长江学者讲座教授

  Email:

michaelzhang@tsinghua.edu.cn

michael.zhang@utdallas.edu


  Postal address:

清华大学医学院90号邮箱 (B305房间) 张奇伟收, 邮编 100084


主要科研领域与方向  Top

计算生物学与生物信息学,合成生物与系统生物学,特别是利用高通量组学技术和高性能计算机模拟,研究细胞发育、分化、凋亡的基因调控和代谢网络,以及它们在癌症等疾病、生物能源、和环境中的应用。

研究及工作经历  Top

  • 1977-1981 中科大近代力学系, 学士
  • 1981-1987 Rutgers U, 统计物理博士
  • 1987-1991 美国NYU Courant Inst.,应用数学博士后
  • 1991-1996 美国冷泉港实验室基因组研究Fellow
  • 1996-1998 美国冷泉港实验室,Assistant Staff
  • 1999-2001 美国冷泉港实验室,Associate Professor
  • 2002-2010 美国冷泉港实验室, Full Professor
  • 2009-至今 清华大学信息学院与医学院双聘教授,生命学院兼职教授, 博导,清华信息国家实验室合成与系统生物实验室主任
  • 2010-至今 美国UT Dallas,Cecil H. and Ida Green Distinguished Chair Professor, Director of Center for Systems Biology

发表论文及著作:  Top

2014

  • Hu L, kai M, Di C, Li Y, Qiu Y, Yu Y, Wang Y, Yang Y-C, Yuan J, Yip KY, Zhang MQ, Lu ZJ (2014) An inter-species feature selection method to characterize non-coding RNAs and their functional domains. Submitted.
  • Heidari N, Phanstiel DH, He C, Grubert F, Jahanbanian F, Kasowski M, Zhang MQ, Snyder MP (2014). Genome-wide map of regulatory interactions in the human genome. Genome Res. pii: gr.176586.114. [Epub ahead of print], PMID:25228660.
  • Sephton CF, Tang AA, Kulkarni A, Brooks M, Stubblefield J, Liu Y, Zhang MQ, Green CB, Huber KM, Huang J, Herz J, Yu G (2014) Activity-Dependent FUS Dysregulation Disrupts Synaptic Homeostasis. PNAS, in press
  • Cheng J, Zhou X, Lu Y, Chen J, Han B, Zhu Y, Liu L, Choy K-W, Han D, Sham PC, Zhang MQ, Zhang X, Yuan H (2014) Exome sequencing identifies a novel frameshift mutation of MYO6 as the cause of autosomal dominant nosyndromic hearing loss in a Chinese family. AHG. In press. PMID:25227905.
  • Sheng MM, Zhong Y, Chen Y, Du JC, Ju XW, Zhao C, Zhang GG, Zhang LF, Liu KT, Yang N, Xie P, Li DS, Zhang MQ*, Jiang CY*(2014) Hsa-miR-1246, hsa-miR-320a and hsa-miR-196b-5p inhibitors can reduce the cytotoxicity of Ebola virus glycoprotein in vitro. SCLS in press.
  • Ouyang W, Liao W, Zhang MQ, Li M (2014) Genome Wide Mapping of Foxo1 Binding-sites in Murine T Lymphocytes. Genomics Data, in press.
  • Nisha Rajagopal, Jason Ernst, Pradipta Ray, Jie Wu, Zhang MQ, Monolis Kellis, and Bing Ren (2014) Distinct and Predictive Histone Lysine Acetylation Patterns at Promoters, Enhancers and Gene Bodies. G3 g3.114.013565; Early Online.
  • Huijun Yuan, Yu Lu, Xueya Zhou, Zhanguo Jin, Jing Cheng, Weidong Shen, Fei Ji, Liyang Liu, Xuegong Zhang, Zhang MQ, Ye Cao, Don Yi Han, and Richard Choy (2014) Resolving the Genetic Heterogeneity of Prelingual Hearing Loss within One Family: Performance Comparison and Application of Two Targeted Next Generation Sequencing Approaches. JHG In press.
  • Li Y, Ehrhardt K, Zhang MQ, Bleris L (2014) Assembly and Validation of Versatile Transcription Activator-Like Effector Libraries. Sci. Rep. 4:4857. PMID:24798576.
  • Li L, Tang J, Zhang B, Yang W, Liugao M, Wang R, Tan Y, Fan J, Chang Y, Fu J, Jiang F, Chen C, Yang Y, Gu J, Wu D, Guo L, Cao D, Li H, Cao G, Wu M, Zhang MQ, Chen L, Wang H (2014) Epigenetic modification of MiR-429 promotes liver tumour-initiating cell properties by targeting Rb binding protein 4. Gut. doi: 10.1136/gutjnl-2013-305715. PMID:24572141.
  • He C, Wang X*, Zhang MQ* (2014) Nucleosome eviction and multiple co-factor binding predict estrogen receoptor alpha associated long-range interactions. Nucl. Acids Res. (2014) doi:10.1093/nar/gku327
  • Li W, Wu J, Kim S-Y, Zhao M, Zhang MQ, Meistrich ML, Mills AA (2014) Chd5 orchestrates chromatin remodeling during sperm development. Nat. Comm. 5:3812. PMID:24818823.
  • Xie P, Liu Y, Li Y, Zhang MQ*, Wang X* (2014) MIROR: a method for cell-type specific microRNA occupancy rate prediction. Mol. BioSyst. 2014,10,1377-1384 DOI:10.1039/C3MB70610A
  • Li GP, Li M, Zhang YW, Wang D, Li R, Guimera R, Gao J*, Zhang MQ* (2014) ModuleRole: a tool for modulization, role determination and visualization in protein-protein interaction networks. PLoS One. 2014;9(5):e94608.
  • Chen L, Zhang H, Li L, Yan Z, Wu DM, Liu Y, Liu K, Liu M, Hu L, Tu Q, Chang Y, Tan Y, Yang C, Song D, Fu J, Yang X, Feng Q, Chen H, Wu M, Yang H, Zhang MQ, Zhang Y, Wang J, Wang H (2014) Integrative whole genome analyses revealing clonal HBV integrations and abnormal enrichment of variable number tandem repeats in human hepatocellular carcinoma. J.Clinical Invest. Submitted.
  • Weyn-Vanhentenryck S, Sun S, Yan Q, Mele A, Farny N, Silver Z, Zhang MQ, Krainer AR, Darnell RB, Zhang C (2014) HITS-CLIP and integrative modeling define the Rbfox splicing-regulatory network linked to brain development and autism. Cell Reports, S2211-1247(14)00084-9. PMID:24613350.
  • Jin Gu, Yang Chen, Huiya Huang, Lingyun Yin, Zhen Xie, Michael Zhang*. Gene module based regulator inference identifying miR-139 as a tumor suppressor in colorectal cancer. Molecular BioSystems 2014, 10(12):3249-3254.

>> 更多

Updated on Nov. 28, 2014