MOE Key Laboratory of Bioinformatics, Tsinghua University     

Alternative Translational Initiation Database

   
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Introduction for the database

Alternative translational initiation is one of mechanisms to increase the complexity level of an organism by alternative gene expression pathways. The use of alternative translation initiation codons in a singe mRNA contributes to the generation of protein diversity. The genes produce two or more versions of the encoded proteins, and the shorter version, initiated from a downstream in-frame start codon, lacks the N-terminal amino acids fragment of the full-length isoform version.

Since the first discovery of alternative translation initiation, a small, yet growing, number of mRNAs initiating translation from alternative start codons have been reported. Various studies began to emerge focusing on this new field in gene expression and revealed the biological significance of the use of alternative initiation. In response to the need for systematic studies on genes invloving alternative translational initiation, Alternative Translational Initiation Database(ATID) is established to provide data of publicly available genes, alternatively translational isoforms and their detailed annotation......

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CITATIONS

Database ATID was established by: Jun Cai and Jing Zhang. For publication of results, please cite:

J. Cai*, J. Zhang*, Y. Huang and Y. Li. ATID: a web-oriented database for collection of publicly available alternative translational initiation events. Bioinformatics, doi:10.1093/bioinformatics/bti704. (*Equally contributed authors)

Zhang J, Cai J, etc. A genome-wide survey of alternative translational initiation events in human. Science in China Series C: Life Sciences. 2007 50 (3): 423-428

 

 

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