Timothy K. Lu

Assistant Professor of Biological Engineering and Electrical Engineering

Synthetic Biology Group, MIT

Title: Synthetic Analog and Digital Platforms for Scalable Biological Computation
Location: FIT 1-315
Time: June 21, 10:00 am

Abstract: Scalable platforms for biological computation in living cells would enable new applications in biotechnology and new strategies for studying biological systems. We describe extensible frameworks for implementing digital and analog computation paradigms with synthetic gene circuits. The digital paradigm enables integrated cellular decision-making and logic and can be achieved with libraries of orthogonal recombinases. The analog paradigm enables wide-dynamic-range biosensing and complex mathematical functions with a parsimonious set of devices. We envision that future efforts in synthetic biology will integrate both digital and analog computation to achieve application-specific goals.