清华合成与系统生物学中心
Tsinghua Center for Synthetic and Systems Biology

DNA copy number aberrations in cancer and evidence-based text mining for cancer

Time: 10:00-12:00 AM, Oct 24, Thu
Place: FIT 1-312
Speaker: Prof. Hyunju Lee, Ph.D., School of Info. & Comm., GIST, South Korea
ABSTRACT: This talk consists of two main parts. First, integrative approaches for the analysis of DNA copy number aberrations (CNAs), gene expressions, protein-protein interactions in cancer are introduced. To find cancer-related genes and pathways, we developed a voting-based cancer module identification method by combining topological and data-driven properties, and a wavelet-based method to distinguish cancer-driving genes from passenger genes. In the second part of the talk, a disease gene search engine, DigSee, is introduced. DigSee is a Web service to search MEDLINE abstracts for evidence sentences describing that 'genes' are involved in the development of 'cancer' through 'biological event. DigSee is available through http://gcancer.org/digsee.